Production of recombinant gonadotropins, FSH and LH, in mammalian cells (CHO).
Production of Gonadotropin Subunits in Mammalian Cells and E. coli.
Reproductive biotechnology
Rara Avis Biotec, SL
Reproductive biotechnology
RARA AVIS BIOTEC, S.L. is a biotechnology company specialized in the production of
recombinant gonadotropins and their use in projects development in order to induce reproductive cycles
in vertebrates.
Our company has produced over 40 recombinant
gonadotropins (FSH and LH) which are specific to different species of teleost fishes, birds, reptiles
and mammals in eukaryotic and prokaryotic expression systems.
In addition, RARA AVIS BIOTEC, S.L. develops antibodies directed
against FSH and LH α and β subunits and immunoassay methods (Western blot, ELISA) to detect the plasma
concentration of these glycoprotein hormones in different vertebrate species.
The recombinant gonadotropins developed by RARA AVIS BIOTEC, S.L.
have shown their efficacy in the induction of reproductive cycles -gonadal maturation in males and
females and collection of functional mature gametes in vivo- and in vitro assays.
|
Ignacio
Giménez Nebot |
José Vicente
Roig Genovés |
RARA AVIS BIOTEC, S.L., is an investee company of
CORPORACIÓN F. TURIA, S.A., the parent company of a Spanish family-owned
business Group with more than 80 years of history.
CORPORACIÓN F. TURIA, S.A. was founded in 1940, being at
the end of the 90’s when it was decided to start a new stage of expansion and
internationalization, as well as diversification in new strategic sectors with high added value. With a
deep restructuring of the Group, the reorganization of all the departmental levels and the incorporation
of a new management team led by the third generation of the founding family, the projects envisaged in
the new strategic planning were undertaken, which mean a rapid growth with an important
investment effort in the acquisition and creation of companies, in the renovation of capital goods
and in research, development and innovation.
Likewise, the CORPORACIÓN F. TURIA, S.A. Group has acquired commitments that
contribute to ethical and responsible growth in all its companies, having been
distinguished with the most renowned national and international certifications of management, product
and environmental systems, being also one of the first business Groups in the Valencian Community to
have obtained the Certification by AENOR of Criminal Compliance Management System, according to UNE
19601.
The CORPORACIÓN F. TURIA,
S.A. Group, has focused on fullfilling what are considered the three fundamental pillars
that will support the present and future of the Group of companies, such as expansion,
diversification and internationalization, which has meant the implementation of a
balanced business model that has successfully combined the old and new Areas of
Activity that make up the Group of companies, being currently present through its subsidiary and
investee companies in varios sectors of activity, with proven experience and specialization in each one
of them, having in turn several consolidated Business Lines, with high quality products of own
manufacture and maximum performance.
The main Areas of Activity as well as the various Business Lines that make them up, and which are
currently being developed through the subsidiary and investee companies of CORPORACIÓN F.
TURIA, S.A. are: CONSTRUCTION MATERIALS (Cement, Concrete, Mortar, Aggregates),
CHEMISTRY (Construction, Fuels, Agriculture), ENVIRONMENT (Treatment and Recovery of Urban Waste,
Ecoparks) and BIOTECHNOLOGY (Recombinant Gonadotropin, Antibodies-ELISA, Development of biological
in vitro tests, Induction of reproductive cycles, Bioinformatics Services &
Data Analytics).
CORPORACIÓN F. TURIA,
S.A. is therefore a business Group made up of a diversified set of companies with a
presence in different sectors and markets, both national and international, oriented towards
sustainable growth, job creation, commitment to the progress of
society, and the generation of sustained profitability, in order to achieve the ultimate
goal of any company, the creation of value for its shareholders.
+info: www.corpturia.com
The primary lines of research and development of RARA AVIS BIOTEC, S.L. focus on:
Production of recombinant gonadotropins, FSH and LH, in mammalian cells (CHO).
Production of monoclonal and polyclonal antibodies against FSH and LH subunits (alpha, beta-FSH and beta-LH) for Western blot, ELISA and immunohistochemistry.
Expression of FSH and LH receptors (FSHR and LHR) associated with reporter genes in eukaryotic cell lines for assay of biological activity of plasma or recombinant gonadotropins.
RARA AVIS BIOTEC, S.L., in collaboration with other companies and Research Groups, develops protocols for the induction of gamete maturation in fish and other vertebrates through the administration of recombinant gonadotropins.
Bioinformatics and data analysis service, to provide support in all the stages that encompass projects for the characterization and induction of the reproductive cycle in vertebrates:
-Advice and design of ad-hoc bioinformatics projects.
-Transcriptomics analysis: Quality control and filtering, RNA-Seq alignment, normalization and quantification, differential expression analysis, functional annotation, and enrichment analysis.
-De novo transcriptome assembly for non-model organisms: Reconstruction and obtaining the transcriptome reference of non-model organisms without reference genome for transcript identification, differential expression analysis, and subsequent analysis.
-Microbiome analysis (16S rRNA, ITS, shotgun metagenomics): Taxonomic classification, data visualization, diversity and functional analysis.
Chauvigné F, Ollé J, González W, Duncan N, Giménez I, Cerdà J. Toward developing recombinant gonadotropin-based hormone therapies for increasing fertility in the flatfish Senegalese sole. PLoS One. 2017;12(3):e0174387. Published 2017 Mar 22.
Chauvigné F, González W, Ramos S, et al. Seasonal-and dose-dependent effects of recombinant gonadotropins on sperm production and quality in the flatfish Solea senegalensis. Comp Biochem Physiol A Mol Integr Physiol. 2018;225:59-64.
Peñaranda DS, Gallego V, Rozenfeld C, et al. Using specific recombinant gonadotropins to induce spermatogenesis and spermiation in the European eel (Anguilla anguilla). Theriogenology. 2018;107:6-20. doi:10.1016/j.theriogenology.2017.11.002
Palstra, A.P., Giménez Nebot, I., Jéhannet, P., Lokman, P.M., Swinkels, W., Heinsbroek, L.T.N. (2019) Testing recombinant gonadotropins for the propagation of European eel (Anguilla anguilla), pretreated by feminization, simulated migration and steroid implants. Aquaculture Europe, October 7-10, Berlin (Germany).
Ramos, S., Chauvigné, F., Gonzalez, W., Rosenfeld, H., Cerdá, J., Giménez, I., Duncan, N. Recombinant follicle-stimulating hormone induces vitellogenesis and spermatogenesis in flathead grey mullet (Mugil cephalus). 11th International Symposium on Reproductive Physiology of Fish: 11 ISRPF 2018: Program and abstracts: 153 (2019)
González W, Ramos S, Giménez I, Duncan N. Sperm contamination by urine in Senegalese sole (Solea senegalensis) and the use of extender solutions for short-term chilled storage. Aquaculture. 2020;516,734649.
Crespo JL, García-Párraga D, Giménez I, et al. Two cases of pseudohermaphroditism in loggerhead sea turtles Caretta caretta. Dis Aquat Organ. 2013;105(3):183-191.
Giménez, I., de la Gandara, F., Arizcun, M., Baixauli, P., Ortega, A., García-Alcázar, A., 2015. Inducción de la vitelogénesis mediante FSH y LH específicas de lubina. XV Congr. Nac. y I Congr. Ibérico Acuic. 172-173.
| Ignacio Giménez Nebot
MD, PhD Scientific director igimenez@raraavis-bio.com |
José Vicente Roig Genovés
Biotechnologist M.Sc. Bioinformatics jvroig@raraavis-bio.com |